I would like to offer you an application to create: I could see that there are skins to people whose eyesight is not soo good, but there aren't any programs to blind people. I think you could make a program what can helps them. My idea is that if they push down some buttons (ALT+CTRL+B for example, 'B' as Blind) the desktop and the whole theme should change to a simplier version: Bigger icons to be easy to find them with the cursor and - this is the point - the cursor could speak or something because the blind people's audition used to be better than the 'healthy' ones. For example if they take the cursor on the startink icon on the corner, it should say that: Menu Bar.